Microparticulate Based Topical Delivery System of Clobetasol Propionate
نویسندگان
چکیده
منابع مشابه
Observations on the systemic effect of topical clobetasol propionate (Dermovate).
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally sma...
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The controlled release of drugs in slow and sustained manner is one of the major challenges in drug delivery system. Targeting of drug to the particular site is an important aspect of drug delivery system. Microparticles were initially developed as carrier for vaccines & anticancer drugs. They have now been used to increase the efficiency of drug delivery system & improve release profile & for ...
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OBJECTIVE We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded. STUDY DESIGN A descriptive pretest/posttest clinical study with no control group (33 patients total) was developed. All patients received repeated applications of 0.05% clobetasol p...
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PURPOSE We report our experience with the use of a topical steroid, 0.05% clobetasol propionate, for the treatment of phimosis with clinical complications. MATERIALS AND METHODS This was a retrospective analysis of the clinical outcomes of all patients presenting with phimosis to a single institution during the time period from October 2008 to May 2012. A total of 88 patients who had a Kikiro...
متن کاملRapid and Simple TLC-Densitometric Method for Assay of Clobetasol Propionate in Topical Solution "2279
A rapid, simple to use and low-cost thin-layer chromatographic procedure in normal phase system with densitometric detection at 246 nm was carefully validated according to the International Conference on Harmonisation (ICH) guidelines for assay of clobetasol propionate in topical solution containing clobetasol propionate in quantity 0.50 mg/mL. The adopted thin-layer chromatographic (TLC)-densi...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2011
ISSN: 1530-9932
DOI: 10.1208/s12249-011-9661-7